Mouse Cre and CreERT2 zoo

Highly-efficient, fluorescent, locus directed Cre and FlpO deleter mice on a pure C57BL/6N genetic background

C57BL/6NTac-Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics/Ics (EM:05488)

In order to facilitate the use of the new mutant resources developed in the mouse, we have generated Cre and FlpO deleter mice on a pure inbred C57BL/6N background. The new transgenic constructs were designed to drive either the Cre or FlpO recombinase, fused to a specific fluorescent marker (respectively the eGFP or the eYFP) and were inserted by homologous recombination in the neutral Rosa26 locus. They allow a rapid, cost-effective and efficient identification of the carrier individuals through the co-expression of the fluorescent marker. The main advantages of these deleters are:

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