MouseCre
Mouse Cre and CreERT2 zoo

Repository

The CreERT2 Zoo is a repository for the collection and distribution of relevant mutant mouse strains essential for basic biomedical research. This mouse resource from the Institut Clinique de la Souris (PHENOMIN-ICS) consists in a collection of about fifty cell specific Tamoxifen inducible Cre driver lines. All lines are available to the scientific community with a materiel transfert agreement (MTA) and available as alive animals and/or frozen materials (embryos/sperm).

To request a line please contact us by email at

Additionally, about fifty CreERT2 knock-in lines are available. As a partner of EUCOMMtools, PHENOMIN-ICS generated them with C57BL/6N Cre knock-in ES cell lines. Their Cre expression patterns are currently under documentation and annotation (named "to be defined" in the summary table) at post-natal day 14 and post-natal day 56. Annotation data will be available soon.


Target cell and tissue Gene Promoter Reference Mutations and alleles Availability Funding program
adipose tissue Adiponectin, C1Q and collagen domain containing hADIPOQ NCBI:9370 transgenic (BAC) Cryopreserved
adipose tissue Fatty acid binding protein 4 adipocyte hFABP4 NCBI:2167 transgenic (BAC) Cryopreserved
adipose tissue Fabp4 mFabp4 MGI:88038 Other Cryopreserved
adipose tissue Uncoupling protein 1 (mitochondrial, proton carrier) hUCP1 NCBI:7350 transgenic (BAC) Cryopreserved
adipose tissue Delta-like 1 homolog mDlk1 MGI:94900 NCBI:13386 transgenic (BAC) Cryopreserved
alpha cells Glucagon mGcg MGI:95674 NCBI:14526 transgenic (plasmid) Cryopreserved
beta cells Insulin 1 mIns1 MGI:96572 NCBI:16333 transgenic (plasmid) Cryopreserved
cardiovascular system Myosin heavy polypeptide 6 cardiac muscle alpha mMyh6 MGI:97255 NCBI:17888 transgenic (BAC) Cryopreserved
central nervous system Neurofilament light polypeptide mNefl MGI:97313 NCBI:18039 transgenic (BAC) Cryopreserved
central nervous system Calcium/calmodulin dependent protein kinase II alpha mCamkIIa MGI:88256 NCBI:12322 transgenic (plasmid) Cryopreserved
central nervous system Purkinje cell protein 2 (L7) mPcp2 MGI:97508 NCBI:18545 transgenic (BAC) Cryopreserved
central nervous system Nestin mNes MGI:101784 NCBI:18008 transgenic (BAC) Cryopreserved
central nervous system Calcium/calmodulin dependant protein Kinase II alpha hCAMKIIa NCBI:815 transgenic (BAC) Cryopreserved
central nervous system Enolase 2, gamma neuronal mEno2 MGI:95394 NCBI:13807 transgenic (BAC) Cryopreserved
central nervous system Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 mSlc6a3 MGI:94862 NCBI:13162 transgenic (BAC) Cryopreserved
central nervous system SRY-box containing gene 2 mSox2 MGI:98364 NCBI:20674 transgenic (BAC) Cryopreserved
central nervous system Plasmacytoma expressed transcript 1 mPet1 MGI:102766 NCBI:107689 transgenic (BAC) Cryopreserved
exocrine pancreatic cells Elastase 1 pancreatic mCela1 MGI:95314 NCBI:109901 transgenic (BAC) Cryopreserved
immune system CD4 antigen mCd4 MGI:88335 NCBI:12504 transgenic (BAC) Cryopreserved
immune system Lymphocyte protein tyrosine kinase mLck MGI:96756 NCBI:16818 transgenic (BAC) Cryopreserved
immune system Macrosialin mCd68 MGI:88342 NCBI:12514 transgenic (BAC) Cryopreserved
immune system Glycoprotein 1b alpha polypeptide mGp1ba MGI:1333744 NCBI:14723 transgenic (BAC) Cryopreserved
immune system CD19 molecule hCD19 NCBI:930 transgenic (BAC) Cryopreserved
immune system Platelet factor 4 mPf4 MGI:1888711 NCBI:56744 transgenic (BAC) Cryopreserved
integumental system Keratin 14 mKrt14 MGI:96688 NCBI:16664 transgenic (BAC) Cryopreserved
integumental system Keratin 5 hKRT5 NCBI:3852 transgenic (BAC) Cryopreserved
integumental system Keratin 10 mKrt10 MGI:96685 NCBI:16661 transgenic (BAC) Cryopreserved
kidney Kidney androgen regulated protein mKap MGI:96653 NCBI:16483 transgenic (BAC) Cryopreserved
macrophages Lysozyme mLyzs MGI:96897 NCBI:17105 transgenic (BAC) Cryopreserved
mucosa (glandular stomach) Ghrelin mGhrl MGI:1930008 NCBI:58991 transgenic (BAC) Cryopreserved
myocytes Troponin I, skeletal, fast 2 mTnni2 MGI:105070 NCBI:21953 transgenic (BAC) Cryopreserved
oocyte Zona pellucida glycoprotein mZp3 MGI:99215 NCBI:22788 transgenic (BAC) Cryopreserved
skeletal system Procollagen type I alpha1 mCol1a1 MGI:88467 NCBI:12842 transgenic (BAC) Cryopreserved
skeletal system Acid phosphatase 5 tartrate resistant mAcp5 MGI:87883 NCBI:11433 transgenic (BAC) Cryopreserved
skeletal system Bone gamma carboxyglutamate protein 1 mBglap1 MGI:88156 NCBI:12096 transgenic (BAC) Cryopreserved
spermatocytes Phosphoglycerate kinase 2 mPgk2 MGI:97563 NCBI:18663 transgenic (BAC) Cryopreserved
ubiquitous Protein phosphatase 1A, magnesium dependent, alpha isoform mPpm1a MGI:99878 NCBI:19042 transgenic (BAC) Cryopreserved
ubiquitous ERT2-iCre-ERT2 DiCre MGI:3793441 Other
to be defined Glutathione peroxidase 3 Gpx3 MGI:105102 targeted (KI) EUCOMMTools logo
to be defined SET and MYND domain containing 3 Smyd3 MGI:1916976 targeted (KI) EUCOMMTools logo
to be defined Aldo-keto reductase family 1, member B7 Akr1b7 MGI:101918 targeted (KI) EUCOMMTools logo
to be defined Homeobox A2 Hoxa2 MGI:96174 targeted (KI) EUCOMMTools logo
to be defined Tachykinin 2 Tac2 MGI:98476 targeted (KI) EUCOMMTools logo
to be defined Insulin-like 3 Insl3 MGI:108427 targeted (KI) EUCOMMTools logo
to be defined Recombination signal binding protein for immunoglobulin kappa J region-like Rbpjl MGI:1196616 targeted (KI) EUCOMMTools logo
to be defined PHD finger protein 21B Phf21b MGI:2443812 targeted (KI) EUCOMMTools logo
to be defined Von Willebrand factor homolog Vwf MGI:98941 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Growth arrest specific 2 Gas2 MGI:95657 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Acyl-CoA synthetase medium-chain family member 4 Acsm4 MGI:2681844 targeted (KI) EUCOMMTools logo
to be defined Anti-Mullerian hormone type 2 receptor Amhr2 MGI:105062 targeted (KI) EUCOMMTools logo
to be defined Growth differentiation factor 9 Gdf9 MGI:95692 targeted (KI) EUCOMMTools logo
to be defined RIKEN cDNA 1700028K03 gene 1700028K03Rik MGI:1923671 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined RNA binding protein, fox-1 homolog (C. elegans) 3 Rbfox3 MGI:106368 targeted (KI) EUCOMMTools logo
to be defined Dopamine receptor D1 Drd1 MGI:99578 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Adiponectin, C1Q and collagen domain containing Adipoq MGI:106675 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined RIKEN cDNA D130043K22 gene D130043K22Rik MGI:3036268 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined CD34 antigen Cd34 MGI:88329 targeted (KI) EUCOMMTools logo
to be defined Aldo-keto reductase family 1, member B7 Akr1b7 MGI:101918 targeted (KI) EUCOMMTools logo
to be defined Doublesex and mab-3 related transcription factor like family C2 Dmrtc2 MGI:1918491 targeted (KI) EUCOMMTools logo
to be defined POU domain, class 2, transcription factor 1 Pou2f1 MGI:101898 targeted (KI) EUCOMMTools logo
to be defined CD3 antigen, epsilon polypeptide Cd3e MGI:88332 targeted (KI) EUCOMMTools logo
to be defined ATPase, H+ transporting, lysosomal V1 subunit G2 Atp6v1g2 MGI:1913487 targeted (KI) EUCOMMTools logo
to be defined Major intrinsic protein of lens fiber Mip MGI:96990 targeted (KI) EUCOMMTools logo
to be defined Polycystic kidney disease 2-like 1 Pkd2l1 MGI:1352448 targeted (KI) EUCOMMTools logo
to be defined Purinergic receptor P2X, ligand-gated ion channel, 7 P2rx7 MGI:1339957 targeted (KI) EUCOMMTools logo
to be defined Neurofilament, heavy polypeptide Nefh MGI:97309 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Spleen focus forming virus (SFFV) proviral integration oncogene Spi1 MGI:98282 targeted (KI) EUCOMMTools logo
to be defined Protein C Proc MGI:97771 targeted (KI) EUCOMMTools logo
to be defined Transient receptor potential cation channel, subfamily C, member 1 Trpc1 MGI:109528 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Platelet derived growth factor receptor, beta polypeptide Pdgfrb MGI:97531 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Msln Msln targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Cell death-inducing DFFA-like effector c Cidec MGI:95585 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Serpinc1 MGI:88095 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Dbi Dbi targeted (KI) EUCOMMTools logo
to be defined Aldolase C, fructose-bisphosphate Aldoc MGI:101863 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Hedgehog-interacting protein Hhip MGI:1341847 targeted (KI) EUCOMMTools logo
to be defined Platelet derived growth factor, B polypeptide Pdgfb MGI:97528 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Perilipin 1 Plin1 MGI:1890505 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined T-complex-associated testis expressed 2 Tcte2 MGI:98641 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Oviductal glycoprotein 1 Ovgp1 MGI:106661 targeted (KI) EUCOMMTools logo
to be defined Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 Gngt2 MGI:893584 targeted (KI) EUCOMMTools logo
to be defined Phosphodiesterase 6C, cGMP specific, cone, alpha prime Pde6c MGI:105956 targeted (KI) EUCOMMTools logo
to be defined Integrin alpha X Itgax MGI:96609 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Parathyroid hormone Pth MGI:97799 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Regulator of G-protein signaling 14 Rgs14 MGI:1859709 targeted (KI) EUCOMMTools logo
to be defined Mucin 5, subtypes A and C, tracheobronchial/gastric Muc5ac MGI:104697 targeted (KI) EUCOMMTools logo
to be defined Corin Corin MGI:1349451 targeted (KI) Cryopreserved EUCOMMTools logo
to be defined Renin 1 structural Ren1 MGI:97898 targeted (KI) EUCOMMTools logo
to be defined HPAX6-GFP-BAC plus transposon PiggyBAC long hPAX6-GFP-BAC plus trans EUCOMMTools logo

informations on the colorimetric floxed reporter mice are indicated in Soriano P, Nat Genet. 1999 Jan;21(1):70-1 Generalized lacZ expression with the ROSA26 Cre reporter strain