The CreERT2 Zoo is a repository for the collection and distribution of relevant mutant mouse strains essential for basic biomedical research. This mouse resource from the Institut Clinique de la Souris (PHENOMIN-ICS) consists in a collection of about fifty cell specific Tamoxifen inducible Cre driver lines. All lines are available to the scientific community with a materiel transfert agreement (MTA) and available as alive animals and/or frozen materials (embryos/sperm).
To request a line please contact us by email at
Additionally, about fifty CreERT2 knock-in lines are available. As a partner of EUCOMMtools, PHENOMIN-ICS generated them with C57BL/6N Cre knock-in ES cell lines. Their Cre expression patterns are currently under documentation and annotation (named "to be defined" in the summary table) at post-natal day 14 and post-natal day 56. Annotation data will be available soon.
|Target cell and tissue||Gene||Promoter||Reference||Mutations and alleles||Availability||Funding program|
|adipose tissue||Adiponectin, C1Q and collagen domain containing||hADIPOQ||NCBI:9370||transgenic (BAC)||Cryopreserved|
|adipose tissue||Fatty acid binding protein 4 adipocyte||hFABP4||NCBI:2167||transgenic (BAC)||Cryopreserved|
|adipose tissue||Uncoupling protein 1 (mitochondrial, proton carrier)||hUCP1||NCBI:7350||transgenic (BAC)||Cryopreserved|
|adipose tissue||Delta-like 1 homolog||mDlk1||MGI:94900 NCBI:13386||transgenic (BAC)||Cryopreserved|
informations on the colorimetric floxed reporter mice are indicated in Soriano P, Nat Genet. 1999 Jan;21(1):70-1 Generalized lacZ expression with the ROSA26 Cre reporter strain