Repository

The CreER^T2 Zoo is a repository for the collection and distribution of relevant mutant mouse strains essential for basic biomedical research. This mouse resource from the Institut Clinique de la Souris (PHENOMIN-ICS) consists in a collection of about fifty cell specific Tamoxifen inducible Cre driver lines. All lines are available to the scientific community with a materiel transfert agreement (MTA) and available as alive animals and/or frozen materials (embryos/sperm).

To request a line please contact us by email at

Additionally, about fifty CreERT2 knock-in lines are available. As a partner of EUCOMMtools, PHENOMIN-ICS generated them with C57BL/6N Cre knock-in ES cell lines. Their Cre expression patterns are currently under documentation and annotation (named "to be defined" in the summary table) at post-natal day 14 and post-natal day 56. Annotation data will be available soon.

------------adipose tissueurogenital systemintegumental systemcentral nervous systemcardiovascular systemimmune systemmuscle and skeletal systemubiquitousdigestive systemto be defined

Target cell and tissue	Gene	Promoter	Reference	Mutations and alleles	Availability	Funding program
central nervous system	Neurofilament light polypeptide	mNefl	MGI:97313 NCBI:18039	transgenic (BAC)	Embryo cryopreserved
central nervous system	Calcium/calmodulin dependent protein kinase II alpha	mCamkIIa	MGI:88256 NCBI:12322	transgenic (plasmid)	Embryo cryopreserved
central nervous system	Purkinje cell protein 2 (L7)	mPcp2	MGI:97508 NCBI:18545	transgenic (BAC)	Embryo cryopreserved
central nervous system	Nestin	mNes	MGI:101784 NCBI:18008	transgenic (BAC)	Embryo cryopreserved
central nervous system	Calcium/calmodulin dependant protein Kinase II alpha	hCAMKIIa	NCBI:815	transgenic (BAC)	Embryo cryopreserved
central nervous system	Enolase 2, gamma neuronal	mEno2	MGI:95394 NCBI:13807	transgenic (BAC)	Embryo cryopreserved
central nervous system	Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	mSlc6a3	MGI:94862 NCBI:13162	transgenic (BAC)	Embryo cryopreserved
central nervous system	SRY-box containing gene 2	mSox2	MGI:98364 NCBI:20674	transgenic (BAC)	Embryo cryopreserved
central nervous system	Plasmacytoma expressed transcript 1	mPet1	MGI:102766 NCBI:107689	transgenic (BAC)	Embryo cryopreserved
central nervous system	Enolase 2, gamma neuronal	mEno2	MGI:95394 NCBI:13807	transgenic (BAC)	Embryo cryopreserved
central nervous system	Nestin	mNes	MGI:101784 NCBI:18008	transgenic (BAC)	Embryo cryopreserved
central nervous system	Calcium/calmodulin dependant protein Kinase II alpha	hCAMKIIa	NCBI:815	transgenic (BAC)	Embryo cryopreserved
central nervous system	Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	mSlc6a3	MGI:94862 NCBI:13162	transgenic (BAC)	Embryo cryopreserved
central nervous system	SRY-box containing gene 2	mSox2	MGI:98364 NCBI:20674	transgenic (BAC)	Embryo cryopreserved
central nervous system	Purkinje cell protein 2 (L7)	mPcp2	MGI:97508 NCBI:18545	transgenic (BAC)	Embryo cryopreserved
central nervous system	Neurofilament light polypeptide	mNefl	MGI:97313 NCBI:18039	transgenic (BAC)	Embryo cryopreserved
central nervous system	Calcium/calmodulin dependent protein kinase II alpha	mCamkIIa	MGI:88256 NCBI:12322	transgenic (plasmid)	Embryo cryopreserved
central nervous system	Plasmacytoma expressed transcript 1	mPet1	MGI:102766 NCBI:107689	transgenic (BAC)	Embryo cryopreserved

informations on the colorimetric floxed reporter mice are indicated in Soriano P, Nat Genet. 1999 Jan;21(1):70-1 Generalized lacZ expression with the ROSA26 Cre reporter strain