Mouse Cre and CreERT2 zoo


The CreERT2 Zoo is a repository for the collection and distribution of relevant mutant mouse strains essential for basic biomedical research. This mouse resource from the Institut Clinique de la Souris (PHENOMIN-ICS) consists in a collection of about fifty cell specific Tamoxifen inducible Cre driver lines. All lines are available to the scientific community with a materiel transfert agreement (MTA) and available as alive animals and/or frozen materials (embryos/sperm).

To request a line please contact us by email at

Additionally, about fifty CreERT2 knock-in lines are available. As a partner of EUCOMMtools, PHENOMIN-ICS generated them with C57BL/6N Cre knock-in ES cell lines. Their Cre expression patterns are currently under documentation and annotation (named "to be defined" in the summary table) at post-natal day 14 and post-natal day 56. Annotation data will be available soon.

Target cell and tissue Gene Promoter Reference Mutations and alleles Availability Funding program
immune system CD4 antigen mCd4 MGI:88335 NCBI:12504 transgenic (BAC) Cryopreserved
immune system Lymphocyte protein tyrosine kinase mLck MGI:96756 NCBI:16818 transgenic (BAC) Cryopreserved
immune system Macrosialin mCd68 MGI:88342 NCBI:12514 transgenic (BAC) Cryopreserved
immune system Glycoprotein 1b alpha polypeptide mGp1ba MGI:1333744 NCBI:14723 transgenic (BAC) Cryopreserved
immune system CD19 molecule hCD19 NCBI:930 transgenic (BAC) Cryopreserved
immune system Platelet factor 4 mPf4 MGI:1888711 NCBI:56744 transgenic (BAC) Cryopreserved
macrophages Lysozyme mLyzs MGI:96897 NCBI:17105 transgenic (BAC) Cryopreserved

informations on the colorimetric floxed reporter mice are indicated in Soriano P, Nat Genet. 1999 Jan;21(1):70-1 Generalized lacZ expression with the ROSA26 Cre reporter strain