Repository

The CreER^T2 Zoo is a repository for the collection and distribution of relevant mutant mouse strains essential for basic biomedical research. This mouse resource from the Institut Clinique de la Souris (PHENOMIN-ICS) consists in a collection of about fifty cell specific Tamoxifen inducible Cre driver lines. All lines are available to the scientific community with a materiel transfert agreement (MTA) and available as alive animals and/or frozen materials (embryos/sperm).

To request a line please contact us by email at

Additionally, about fifty CreERT2 knock-in lines are available. As a partner of EUCOMMtools, PHENOMIN-ICS generated them with C57BL/6N Cre knock-in ES cell lines. Their Cre expression patterns are currently under documentation and annotation (named "to be defined" in the summary table) at post-natal day 14 and post-natal day 56. Annotation data will be available soon.

------------adipose tissueurogenital systemintegumental systemcentral nervous systemcardiovascular systemimmune systemmuscle and skeletal systemubiquitousdigestive systemto be defined

Target cell and tissue	Gene	Promoter	Reference	Mutations and alleles	Availability	Funding program
ubiquitous	Protein phosphatase 1A, magnesium dependent, alpha isoform	mPpm1a	MGI:99878 NCBI:19042	transgenic (BAC)	Embryo cryopreserved
ubiquitous	ERT2-iCre-ERT2	DiCre	MGI:3793441	Other
ubiquitous	ERT2-iCre-ERT2	DiCre	MGI:3793441	Other
ubiquitous	Protein phosphatase 1A, magnesium dependent, alpha isoform	mPpm1a	MGI:99878 NCBI:19042	transgenic (BAC)	Embryo cryopreserved

informations on the colorimetric floxed reporter mice are indicated in Soriano P, Nat Genet. 1999 Jan;21(1):70-1 Generalized lacZ expression with the ROSA26 Cre reporter strain